Cheslin Kolbe returns to the side after an ankle injury as the Springboks bid to avenge their "Miracle of Brighton" defeat to Japan at the 2015 World Cup in Tokyo on Sunday.
Shoaib Malik will take over from West Indian powerhouse Chris Gayle who will exit the Jozi Stars post their sixth game.
Aiden Markram will miss the third Test against India due to a wrist injury after striking something in frustration.
Lionel Messi won the trophy for a third straight year after scoring 36 goals, three more than his closest challenger, Kylian Mbappe of Paris Saint-Germain.
In an exclusive interview with EWN Sport, Horn denied taking the banned substances, saying she was not guilty of any wrongdoing and together with her legal team were trying to find out what happened, as things occurred so fast.
Japan know they will need all their wits about them against the experience of two-time champions South Africa in Tokyo on Sunday.
Once labelled too small to play for the Springboks and told to consider a shift to scrumhalf if he wanted to play top-level rugby, the 25-year-old has silenced his critics with his electrifying pace and nimble side-stepping.
Rory McIlroy stoked the fires by saying he used a rivalry mentality to help him win the season-ending Tour Championship at East Lake at the end of August.
Imbokodo claimed the Rugby Africa Women's Sevens crown in Tunisia after edging Kenya 15-14 on Sunday.
The race, which starts a week earlier than usual on 27 June to accommodate the Tokyo Olympics, has eight mountain stages and three hilly stages and should suit the 2019 champion Egan Bernal and his Ineos teammate Chris Froome.
