The Lions prop is replaced in the run-on 15 by Dylan Smith with Nathan McBeth coming onto the bench.
The cancellation comes on the back of Zambia also pulling out on a planned friendly they were due to play with South Africa on 7 September.
Abongile Nonkontwana and Gerhard Olivier switch places, with Oliver starting on number 6 flank.
Williams is seeking a 24th Grand Slam singles title to match Margaret Court's all-time record and will face either Belinda Bencic or Bianca Andreescu on Saturday in her bid for a record seventh US Open triumph.
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For decades, SA women have been crying out for help, pleading for the war against us to end. Today, the women of Primedia Broadcasting take a stand.
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There were protests against gender-based violence in Parliament this week following the murder of several women and children including UCT student Uyinene Mrwetyana and boxer Leighandre Jegels.
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The Rapper gave the news to her 20 million Twitter followers, although she had not previously said she was either pregnant or married.
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The calls by the stores come as the United States grapples with an epidemic of gun violence and frequent mass shootings.
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A report by Oxfam and Development Finance International shows that the wealthiest 1% of West Africans own more than everyone else in the region combined.
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